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In another casecontrol study, each Danish patient exposed to GLP-1a exhibited the lowest risk of major CI compared to all other antidiabetic drugs combined (no head-to-head comparisons) [HR (95% CI) = 0.89 (0.860.93)] [14]

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But they have different strengths and for different purposes

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Strategies to Prevent Hypoglycemia While Using Semaglutide If you take semaglutide with insulin or sulfonylurea drugs, your provider should reduce the dose of those medications to lower hypoglycemia risk