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B12 and related B vitamins are worth special attention because many compounded GLP-1 formulations include B12 with semaglutide or B12 with tirzepatide precisely because reduced food intake lowers B vitamin status

32 Furthermore, the recent FDA approvals of generic liraglutide and exenatide offer the potential for increased affordability and access to GLP-1 RA therapies

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Leptin gene therapy improves type1 and type2 diabetes and diet-induced obesity in animal models, such as ob/ob, diet-induced obese mice, insulin-deficient type 1 diabetes mice, and insulin-dependent diabetes animals

Some patients report chills alongside other systemic responses such as fatigue, headache, or body aches during the first 24 weeks of semaglutide therapy
