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Description
Using these data, we conducted a large genome-wide association study (GWAS), and identified robust evidence that variants in the GLP1R locus are associated with both differential weight loss and side effects

We assessed the quality of the studies with the risk of bias assessment tool for randomized controlled trials and the Risk of Bias in Non-randomized Studiesof Interventions (ROBINS-I) tool for nonrandomized trials

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The clinical trials, called LEAD, SUSTAIN, PIONEER, STEP, and SURPASS (youve got to just love the creative acronyms!) have generated data that are hard to dismiss: Glycemic Control : These drugs consistently outperform most oral antidiabetics in lowering blood sugar by 10 to 20 percent

Am Heart J 2010;159:612619.e3

GLP-1 agonists such as Wegovy (semaglutide) and Zepbound (tirzepatide) have demonstrated up to 20% body weight reductions in pivotal trials an efficacy previously thought achievable only through bariatric surgery