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Description
The targets are small molecules

doi: 10.2337/dci19-0014

Contact your provider promptly if you experience severe or persistent gastrointestinal symptoms while using both medications, including: severe diarrhea lasting more than 24 hours, signs of dehydration (decreased urination, dizziness, extreme thirst, dry mouth), persistent vomiting preventing adequate fluid intake, severe abdominal pain or cramping, or blood in stool

Phentermine is a stimulant-based appetite suppressant that works through different mechanisms than semaglutide

Oral Medications and Semaglutide Absorption Issues Semaglutide slows how quickly food and liquids move through your stomach, which can reduce how much your body absorbs certain oral medications
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