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Ananthanarayanan M, Balasubramanian N, Makishima M, et al

Safety assessment of GLP-1RAs In terms of nausea, 11 studies (with 429 and 378 subjects from the experimental and control groups, respectively) were included for analysis

A post-hoc analysis of SUSTAIN 6 and PIONEER 6 trials identified an emerging cardiovascular signal: MACE risk reduction with semaglutide was numerically stronger in the metformin subgroup (HR 0.70) versus those without metformin (HR 0.86), a directional finding suggesting the combination may carry cardiovascular benefit beyond glycaemic control

The key safety advantage of compounded therapy lies in dose customization and integration with genetic predisposition testing for tailored medical supervision

With those caveats stated clearly, here is what practitioners who are using this approach are documenting

Dulai, P