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25 however, emerging evidence supports the notion that intestinal SMCs are affected functionally and structurally by most inflammatory conditions involving the intestine leading to altered morphology and contractile behavior, and secretion of various inflammatory mediators

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Several real-world analyses through 2025 have started to show precisely that a modest reduction in stone events among GLP-1 users, in some cases independent of blood-sugar control

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Cao B, Chen Y, Brietzke E, Cha D, Shaukat A, Pan Z, et al