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MIN6 cells were pretreated with 1 mM metformin for 2 h (thin dotted line of left panel) or simultaneously with 10 nM GLP-1 (thick dotted line of left panel)

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I cannot seem to identify any other rationale from the literature as to why 30-60 minutes before food

Over half of all individuals on semaglutide lost at least 15% of their bodyweight, and 34.8% lost more than 20%