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Management of Hyperglycaemia in Type 2 Diabetes, 2022

doi: 10.1038/labinvest.2017.95 63

Trial data have shown decreases in serious cardiovascular complications, including cardiovascular mortality, nonlethal heart attacks, and nonfatal cerebrovascular accidents, among individuals with type 2 diabetes and pre-existing cardiovascular pathology or high cardiovascular risk [3,5,13,14,37]

In a range of animal models of AD or PD, these dual agonists were more effective than exendin-4, liraglutide, semaglutide, or tirzepatide [130, 136, 177, 212,213,214]

GLP-1 receptor agonists stimulate insulin secretion, suppress glucagon, slow gastric emptying, and reduce appetite through multiple physiological pathways

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