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Take your first dose on a Friday If possible, time your first injection for a Friday afternoon or evening

Of 152 participants, the average additional weight loss after switching was 2.1 kg over 12 weeks
For detailed storage protocols, our guides on whether tirzepatide needs refrigeration and how long tirzepatide lasts in the fridge cover every scenario including travel storage, power outages, and shipping considerations

The SURPASS and SURMOUNT trials have led the ADA to consider tirzepatide, along with semaglutide, to be very highly efficacious for weight loss [38]

PMCID: PMC12210098
Tirzepatide 5mg is widely used in research protocols as the first escalation dose after the 2.5mg initiation phase
