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These include limited long-term safety data across diverse populations, insufficient understanding of mechanisms in neuropsychiatric and oncologic contexts, and suboptimal communication between clinicians and patients

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307,308 Among the known pathogenic genes associated with HCM, mutations in MYBPC3 (myosin-binding protein C3) are the most prevalent, 309 with the majority being loss-of-function variants that result in haploinsufficiency

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[10:17] C Yes

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