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[DOI] [PMC free article] [PubMed] [Google Scholar] 93.The effect of GLP-1RA exenatide on idiopathic intracranial hypertension: a randomized clinical trial

Better safety profile : Serious side effects were less common in people taking liraglutide (7%) compared to those getting placebo (18%)

Indeed, some semaglutide users without IBS already report constipation as a side effect, and in an IBS-C patient whos prone to sluggish bowels, the added delay can lead to harder, less frequent stools

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The company also offers a "taper-off guarantee" by providing a protocol for users to gradually reduce reliance on the medications while maintaining their weight loss, the company said in a press release

NICE recommends a 4-8 week trial of full-dose PPI therapy, followed by stepping down to the lowest effective dose or on-demand treatment