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The GWAS was performed including covariates as described in equation 1 above, with the addition of five genetic principal components to account for fine-scale genetic ancestry, and indicator variables to account for variation in the genotyping platform

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In primary human hepatocytes, adiponectin can also increase MMP-9 mRNA and enzymatic activity [184], which plays a bidirectional regulatory role in different fibrotic diseases or different stages of the same fibrotic disease [115]

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