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Dosing and Titration Used in Clinical Trials In Phase 2 trials, retatrutide was given as a once-weekly subcutaneous injection escalating from 2 mg at weeks 14 up to 12 mg from week 12 onwards

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Our findings demonstrated that both natural and synthetic GLP-1 administration altered heat sensitivity and that local administration of GLP-1 notably reduced heat sensitivity and CAP-induced spontaneous pain behavior

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