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191 The mechanism of GLP-1 RA to improve dopaminergic degeneration and pathological -synuclein aggregation in the PD model may involve inhibiting the PI3K/Akt/mTOR pathway 192 and enhancing AMPK/PGC-1a signaling pathway

Maintenance and Long-Term GLP-1 Use Many patients transition from active weight loss phases to maintenance doses, where they stay on lower medication amounts indefinitely to prevent weight regain

Q: Will the weight stay off after stopping

Starting with a lower dose and gradually increasing helps minimize discomfort during this adjustment period.

Its about understanding the simple metabolic science behind weight loss and using the tools that work with your body

It is primarily determined by your lean muscle mass