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Additionally, GLP-1 agonists improve metabolic functions by increasing the production of short-chain fatty acids like butyrate, propionate, and acetate, which serve as energy sources for colonocytes, modulate immune responses, and enhance the production of gut hormones that regulate appetite and glucose homeostasis

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Tirzepatide is a dual agonist that targets both GLP-1 and GIP receptors, which is why clinical trials have shown even greater weight loss over 20% of body weight in some studies compared to semaglutide's average of 15%