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Abstract Background Renin-angiotensin system inhibitors (RASi) and sodium glucose cotransporter inhibitors (SGLT2i) are known for their kidney protective properties, but both show significant residual risk in large outcome trials

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Additional factors, such as obesity, alcohol consumption, and smoking, can also increase the risk of pancreatitis, irrespective of drug therapy

Losing weight at a steady pace Research shows that when you lose weight quickly, youre more likely to lose a greater share of muscle and potentially bone mass as a proportion of the total weight you lose

Side effects include dizziness, vomiting, and diarrhea

If twice-weekly dosing were explored, it would involve splitting the intended weekly dose or using lower individual doses more frequently