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AAPS J (2016) 18(2):38594

In summary, the relatively higher expression of GLP-1R on -cells allows GLP-1 to indirectly inhibit glucagon secretion by promoting somatostatin secretion

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Activation of the GLP-1R stimulates the PI3K/Akt/mTOR pathway, which in turn upregulates the expression of antioxidant enzymes and reduces ROS production

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