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showed that over-expression of polycystin-2 increased the EGF-induced inward currents in kidney epithelial cell lines

[32] Ji, L., Gao, L., Jiang, H., Yang, J., Yu, L., Wen, J.,

SARS-CoV-2 and pancreatic cells injury Through the cellular injury induced by SARS-CoV-2, the activation of inflammasomes results in the conversion of pro-inflammatory cytokines to inflammatory cytokines

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This effect may diminish over time (tachyphylaxis) and varies between individuals, as noted in the Wegovy SmPC
