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A pancreas-tropic series of ionizable LNPs based on DLin-MC3-DMA analogues selectively delivered luciferase messenger ribonucleic acid (mRNA) to -cells in vivo [116]

Henry R

T.ShiraiM.PearsonJ

First, PKA phosphorylates CREB, which simultaneously promotes anti-inflammatory IL-10 transcription and directly inhibits NF-B nuclear translocation, reducing TNF-, IL-6, and IL-1 production