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Exenatide once weekly: sustained improvement in glycemic control and cardiometabolic measures through 3 years

Effects of exenatide on systolic blood pressure in subjects with type 2 diabetes
Quick Answer: Weaning off tirzepatide without weight regain requires medical supervision for potential dose tapering, intensified lifestyle modifications including 200300 minutes weekly of physical activity, protein-optimized nutrition, behavioral strategies like regular self-weighing, and realistic expectations about the biological tendency toward weight regain after discontinuation

Nauck MA, Mller TD

Why does weight loss plateau, and what happens when you quit

These developments underscore a broader trend where obesity medicines are evolving into whole-body therapies with implications across multiple disease states
