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If you have diabetic retinopathy, for example, GLP-1 medications may not be the best choice

Key findings Within six months of starting GLP-1 therapy, the rate of hypotensive events increased from 8.7% to 10.2% The increased risk remained significant at 12 months, with hypotensive events rising from 13.6% to 14.3% Adults age 65 and older accounted for 53% of hypotensive events despite representing 37% of the study population Patients with Type 2 diabetes made up 75% of those experiencing hypotensive episodes but only 63% of the overall cohort In secondary analyses, the scientists found that weight loss alone did not explain the increased risk, suggesting other mechanisms of action may be at play Below is a Q&A with study senior author Dr

Amgen did say on the call that it has initiated six global Phase III studies for the drug, with more planned this year

Factors such as current weight, age, health status, activity level, and consistency with treatment and follow-up can all influence your individual weight loss experience

GLP-1RA intervention was not associated with higher diarrhea events when compared to the patients given metformin or placebo (OR = 2.06

The SCALE clinical trials were designed to assess the effectiveness and safety of this agent for weight loss in patients with obesity or overweight (BMI 27kg/m2) with comorbidities