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11 Conclusion Glucagon-like peptide-1 receptor agonists are pivotal in managing T2DM and obesity, enhancing glycaemic control by boosting insulin secretion, reducing glucagon levels, delaying gastric emptying, and promoting satiety

Dose titration is gradual over several months to minimise gastrointestinal side effects including nausea, vomiting, and diarrhoea

Secondary prevention: Reducing the risk of recurrent ASCVD events in individuals with established atherosclerotic cardiovascular disease

Glucose-dependent insulinotropic polypeptide reduces fat-specific expression and activity of 11beta-hydroxysteroid dehydrogenase type 1 and inhibits release of free fatty acids

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