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While metformin remains the first-line treatment for T2D, GLP-1s may be used in combination with metformin for additional benefits

I = 41.4%, p = 0.103)

Cost effectiveness of sodium-glucose cotransporter-2 (SGLT2) inhibitors, glucagon-like peptide-1 (GLP-1) receptor agonists, and dipeptidyl peptidase-4 (DPP-4) inhibitors: a systematic review

Diabetologia 65 (8), 12511261

Probiotic benefits typically emerge after 48 weeks of consistent daily use, though evidence for metabolic outcomes remains limited

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