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Description
When cultured human L-cells were deprived overnight of glucose and serum and then exposed to high glucose, 10% FBS, and -carrageenan (1g/ml) for 10minutes, 1h, and 24h, mRNA expression of proglucagon and secretion of GLP-1 were significantly reduced, compared to control cells not exposed to carrageenan
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Dulaglutide (100 nM) augmented the phosphorylation state of phospholamban at serine 16 and the phosphorylation state of the inhibitory subunit of troponin
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