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In contrast, lean male and female PAR2-R38E mice showed a significant reduction not only in postprandial GIP, but also in GLP-1 levels in the plasma (Figure 1, G and H), suggesting that additional proteases directly or indirectly participated in GLP-1 regulation specifically during food intake

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( D ) Plasma concentrations of ghrelin in fasted male and female Tmprss2 / and WT mice on a HFD for 14 weeks