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Parkman HP, Misra A, Jacobs M et al

As established in animals, ghrelin and GLP-1 are well positioned as signaling agents within the gutbrain axis to regulate food intake and modulate motivational and reward-related behavior by increasing and decreasing reward responses, respectively

Xing C, Zhang J, Zhao H, et al

Obesity 23:S1S26 Magkos F, Fraterrigo G, Yoshino J et al (2016) Effects of moderate and subsequent progressive weight loss on metabolic function and adipose tissue biology in humans with obesity

That's exactly why I put together this roundup
Keep a simple mood log, even just a daily score out of ten, to spot trends early