oral glp-1 agonist The challenge of developing alternatives to Ozempic, Wegovy and Mounjaro Novel oral GLP-1 receptor agonist
Description
Liraglutide (Saxenda) was one of the earlier forms of longer-lasting GLP-1s and reduces HbA1c (average blood glucose) levels by around 1.3% on average and fasting plasma glucose by 2 mmol/L
In another study, semaglutide exhibited greater potency in activating GLP-1R compared to GLP-1, with an EC50 of 6.2 pM for semaglutide vs 16.2 pM for GLP-1 (95) (The variability in EC50 values among different studies for GLP-1 was not uncommon attributable to varying assay conditions)

These medications, which mimic the functions of the naturally occurring hormone GLP-1 (glucagon-like peptide-1), have been lauded for their efficacy in not only controlling blood sugar levels but also promoting weight loss

Endocrinology and Metabolism

Other common side effects include headaches, injection site reactions, and nasopharyngitis, but these do not usually result in discontinuation of the drug [74-77]

[DOI] [PubMed] [Google Scholar] 324.Brubaker P.L., Anini Y
