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doi: 10.1111/nmo.13196

First, it nudges your pancreas to release insulin so that sugar doesnt float around in your blood but instead gets moved into your cells to be used for energy

Tirzepatide became the first dual GLP/GLP-1 receptor agonist to gain FDA approval for treating T2DM in 2022 and obesity in 2023 [ Table 2 ]

Ferrannini G, Gerstein H, Colhoun HM, et al

The FDA has escalated enforcement against compounded GLP-1 marketing since September 2025, Novo Nordisk launched the first FDA-approved oral semaglutide pill in January 2026, and compounding pharmacy supply chains are narrowing as regulatory pressure increases
Around three and a half years ago, my then internet friend (and now my cofounder at my virtual clinic, Vineyard), Spencer Nadolsky, DO, tweeted something that hit me hard
