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Leptin participates in normal hippocampal dendritic spine formation through activation of TRPC channels in hippocampal neurons [145]

Calculations of mean difference (MD) and standardized mean difference (SMD) were used to synthesize continuous variables, such as the change from baseline in HbA1c, body weight, or eGFR

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Phase 3 TRIUMPH trials run at Canadian sites in provinces including Ontario, Quebec, and British Columbia, with investigational access restricted to trial participants

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