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Abstract Purpose of Review The pharmacologic management of type 2 diabetes prioritises sodium-glucose cotransporter 2 (SGLT-2) inhibitors or glucagon-like peptide 1 (GLP-1) receptor agonists for their demonstrated cardiovascular benefits in individuals with atherosclerotic cardiovascular disease or multiple cardiovascular risk factors, chronic kidney disease, and heart failure

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In addition to its effects on insulin and glucagon, GLP-1RAs work on the brain for an anorexigenic effect by promoting feelings of satiety and modulating energy homeostasis

10.1172/JCI68815 80 LiuZ.LiaoW.ZhangZ.SunR.LuoY.ChenQ.et al (2021)

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