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Description
Studies were included regardless of publication status or language, but we excluded any preclinical studies (animal or in vitro), case reports or small case series (sample size 90% in most cohorts) and obese (mean BMI ~ 3542 kg.m 2 )

The optimal interpretation of data may be hampered due to the small sample size or high study heterogeneity

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Bioconjug Che

It is therefore reasonable to hypothesize that sustained weight loss could reduce cancer risk

A BMI of 28 falls within the 27-29.9 overweight range where the comorbidity pathway applies
