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Weight loss drugs like semaglutide (Wegovy) and tirzepatide (Zepbound) continue to have their moment in the medical space

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The primary endpoint was the percentage weight loss at six months (M6) compared to baseline

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This evolutionary path is fundamentally different from the generally accepted idea that conflicting functions in a single gene favour duplication and diversification, as is the case for Exendin-4 in gila monster

However, cardiovascular safety trials in type 2 diabetes patients, the majority presenting cardiovascular disease and excess weight, showed that GLP-1 receptor agonists were indeed capable of decreasing cardiovascular risk