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Semaglutide remains an important model for understanding GLP-1 receptor biology and will continue to contribute valuable insights into metabolic signaling

In the PIONEER 5 trial, in which patients had moderate renal impairment, there were two cerebrovascular events in the semaglutide group and none in the placebo group

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however, high basal leakiness in the absence of TSH resulted in poor inducibility

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