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Conclusions GLP-1RAs had a neutral effect on the composite cardiovascular outcomes but reduced composite kidney events in the patients with advanced DKD compared with DPP-4is.

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T2DM , .GLP-1/GIP/GCG SignalingFigure 1

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Retatrutide is an investigational triple-receptor agonist studied for its activity on GLP-1, GIP, and glucagon receptorskey pathways involved in appetite signaling, glucose regulation, energy balance, and metabolic adaptation