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An alternative possibility, therefore, is that glutamine in some way potentiates the secretory response, analogous to the effect of glucose on pancreatic beta cells [31]

In Vivo Assessment of Drug Interactions Effects of Sitagliptin on Other Drugs In clinical studies, sitagliptin did not meaningfully alter the pharmacokinetics of metformin, glyburide, simvastatin, rosiglitazone, digoxin, warfarin, or an oral contraceptive (ethinyl estradiol and norethindrone) (Table 4), providing in vivo evidence of a low propensity for causing drug interactions with substrates of CYP3A4, CYP2C8, CYP2C9, P-gp, and organic cationic transporter (OCT)

Zhao Y, Zhang Y, Yang L, Zhang K, Li S

Peptides 95: 124127

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