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While a definitive causal relationship has not been established, the occurrence of acute pancreatitis necessitates immediate drug withdrawal, as recommended by the American Diabetes Association and the American College of Cardiology ( Treatment cessation should also be considered in patients who develop gallbladder complications, such as acute cholecystitis
In the SUSTAIN-6 trial, injectable semaglutide demonstrated a notable effect in reducing the incidence of nonfatal stroke (hazard ratio [HR] 0.61

Two clinical trials were done on semaglutide and Alzheimers, and they did not show any benefits, Low Wang said
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Challenges include gastrointestinal side effects, nutritional deficiencies due to calorie reduction, muscle and bone loss, low long-term adherence with subsequent weight regain, and high costs, resulting in low cost-effectiveness

That, combined with possible nutritional deficiencies from eating less, could lead to shedding
