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Limitations Side effects can be more pronounced initially (nausea, diarrhea)

Can biomarkers predict which patients will experience significant shedding before it occurs

Clinical trials and real-world data show that gastrointestinal side effectsincluding nausea, vomiting, and refluxoccur in a meaningful proportion of GLP-1 users

Trial data from STEP 4 (semaglutide) and SURMOUNT-4 (tirzepatide) show most of the weight is regained over 5288 weeks after discontinuation

Unlike medications like Semaglutide, traditional weight loss methods dont rely on external aids

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