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Among the marketed large molecule injectable GLP-1 agonists, semaglutide, apart from weight-loss, is being studied for kidney disease and tirzepatide (a dual GLP-1 and GIP receptor agonist) is being evaluated for sleep apnea in Ph 3 clinical trials

GLP-1 receptor expression in renal pelvis, densely innervated by afferent renal nerve, was assessed by real-time PCR and western blot analysis

If you're taking GLP-1 medications like Ozempic, Wegovy, Mounjaro, or Zepbound, you've likely experienced the dreaded side effects: nausea, fatigue, reduced appetite, and sometimes vomiting or diarrhea

The Trump administration announced agreements with Eli Lilly and Novo Nordisk to reduce the prices of the companies GLP-1 drugs.

Eli Lilly and Novo Nordisk are closing in on deals with the Trump administration that would exchange deep discounts on their weight loss drugs for coverage under Medicare, per Endpoints News

Purpose of Review This review summarizes the current understanding of the physiologic influence of GLP-1 RAs on gastrointestinal motility, highlights key clinical implications of these effects, and defines areas for future investigation