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For legitimate research sites operating under investigational new drug (IND) requirements, the letter has limited impact

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Thus, it supports the usefulness of GLP-1 and its analogs in the management of type 1 diabetes (210)

GLP-1 medications are known as subcutaneous injections, which means they must be injected under the skin and into the fatty layer just below the surface

Food intake and energy expenditure in the short term are modulated by a wide variety of situational and meal-related factors, among the most important are short-term gut derived hormones such as GLP-1 that act to signal acute energy status

The table below puts them side by side on the points that matter most to dosing decisions