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The authors hypothesized that semaglutide improved steatosis by increasing FA -oxidation and by decreasing hepatic glucose uptake and ER stress and that it improved inflammation by affecting the cytokine and adipokine profile [30]
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[DOI] [PubMed] [Google Scholar] 94.U
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It augments the effects of insulin on its cellular targets (especially in the adipose tissue) and has shown cardiovascular benefits in randomized controlled trials (RCTs), meta-analyses of several prospective studies and large observational studies [45, 46]
Yet most primary care physicians (PCPs) are skeptical of telehealth platforms prescribing GLP-1s for weight loss
