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These include: Nausea (very common, affecting more than 1 in 10 people) Diarrhoea and vomiting (common) Abdominal pain and decreased appetite Dyspepsia (indigestion) and constipation These gastrointestinal symptoms are typically most pronounced when starting treatment or increasing the dose, and often diminish over time as the body adjusts to the medication

If ondansetron is required beyond the initial adjustment period, your clinician may investigate whether dose adjustment of Wegovy or alternative weight management strategies might be more appropriate

The estimated background risk of birth defects and miscarriage for the indicated population is unknown

Another hormone that is an important target for new drugs in diabetes and obesity is glucagon

Hypoglycemia is a risk when tirzepatide is used in combination with insulin or insulin secretagogues (such as sulfonylureas)