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References Wegovy (semaglutide 2.4 mg) Prescribing Information U.S

This is due to increased small intestinal sodium/glucose cotransporter 1 (SGLT1) expression and subsequent GLP-1 release following intestinal glucose infusion, which are mediated by metformin-induced alterations in the small intestinal microbiota 131

Additionally, the risk of pancreatic cancer was 59% lower, and the risk of hepatocellular carcinoma was 53% lower

However, our preliminary results suggest this combination therapy has potential as a rejuvenation treatment

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Semaglutide in SUSTAIN-6 trial reduced the risk of MACE by 26% in patients with T2D, mostly by reducing rate of nonfatal stroke (39%) compared to placebo