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Pros: One-time treatment Long-term weight loss supported by decades of research Often improves diabetes, blood pressure, and sleep apnea No lifelong medication costs Cons: Requires surgery and recovery Lifestyle changes are necessary For many patients with severe obesity, bariatric surgery remains the most effective long-term treatment available

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This increased activation was correlated with clinical improvements in PD symptoms

It is widely considered the gold standard go-to diabetes medication by the American Diabetes Association due to its decades-long safety profile and affordability as a generic medication

Larger reductions in A1c were generally seen with higher doses of SGLT2-I and amongst patients with higher baseline A1c values

Weight goals should be managed with a plan that considers nutrition, activity, other conditions, and medication risks