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In recent years, the treatment landscape for obesity has evolved rapidly, with GLP-1 (glucagon-like peptide-1) agonists emerging as a powerful tool in weight management

for example, an analysis of realworld data from the UK showed that liraglutide reduced HbA 1c to a greater extent than lixisenatide (mean treatment difference [95% confidence interval (CI)] 0.3%point [0.56

41 In a meta-analysis of nine RCTs involving 8,920 patients with HF and coexisting T2D, GLP-1 RAs did not improve LVEF, LV end-diastolic volume or LV end-systolic volume

Almost all exposures were unintentional ( n = 143, 94%)

C., Chao, A

Reviewed by Paul Holmes Paul Holmes Director of Science and Innovation at Naturecan Testing for large pharmaceutical & tobacco companies, Paul has built a wealth of scientific and regulatory knowledge, working on regulatory submissions to bodies such as the FDA and the MHRA