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Saxenda (Liraglutide) is the only GLP-1 medication approved in Singapore for weight loss

As the term implies, microdosing GLP-1s entails taking a smaller dose (or a less frequent dose) than whats typically prescribed

Semaglutide is known to cause diarrhea, emesis, and decreased oral intake

Manufacturer savings programs: Eli Lilly will likely offer a savings card similar to Mounjaro's, potentially reducing out-of-pocket costs to $25$50/month for commercially insured patients Projected price: List price estimated at $1,000$1,500/month based on tirzepatide's pricing Brand name: Eli Lilly will give it a commercial brand name (similar to tirzepatide becoming "Mounjaro" and "Zepbound") For more on FDA status, trial progress, and what approval will mean for access and cost, see our guide: Is Retatrutide FDA Approved

PT referral if there are any physical barriers to exercise

High glucose levels lead to the creation of advanced glycation end products (AGEs), which contribute to fibrotic tissue formation [28], and both AGEs and excess insulin can promote fibroblast proliferation and ECM production [29,30]