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OCR was determined with the Seahorse technology

Paradoxically, these findings indicate that similar results can be obtained by combining GLP-1 receptor activation with either GIP receptor agonism or GIP receptor antagonism

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However, the challenge with current TRPV1 antagonists lies in their associated adverse effects, such as hyperthermia 24,25,26,27,28,29,30,31 and hypothermia 32,33,34 , caused by failures in thermoregulation

The updated model emphasizes that aging is not driven by a single mechanism, but emerges from a network of interacting biological systems that link molecular damage to systemic physiological decline

Extracted RNA was amplified by Brilliant SYBR Green qRT-PCR Master Mix kit (Agilent, Santa Clara, CA) utilizing mouse gene specific primers for IL-1