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Worsened Side Effects: These medications can already cause nausea or stomach upset, especially when you are first adjusting to them

Glucagon-like peptide-1 receptor agonists (GLP1-RAs) not only act by reducing body weight but also can affect the mechanisms involved in insulin resistance, like an increasing expression of glucose transporters in insulin-dependent tissues, decreasing inflammation, reducing oxidative stress, and modulating lipid metabolism

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If Wegovy is covered and Zepbound isn't, you'll need prior authorization to switch, often requiring documentation that Wegovy failed or caused intolerable side effects

The risk of gastric ulcers and gastrointestinal bleeding is a well-established concern with NSAIDs, particularly with prolonged use, higher doses, or in patients over 65 years of age