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GLP-1 agents should be discontinued 2 months before planned conception

Despite the widespread use of SSRIs in geriatric populations and the well-documented risks they face, there remains a concerning paucity of adequately powered prospective clinical trials specifically designed to define optimal dosing regimens, establish therapeutic windows, and develop evidence-based monitoring protocols tailored to the unique physiological characteristics and clinical contexts of elderly patients [55,73]

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Notably, unlike GLP-1, we did not detect any alterations in the levels of glucose-dependent insulinotropic polypeptide (GIP), another incretin hormone, and its ileal expression in MMI mice after T3 treatment (Supplementary Fig