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A recently published, randomized, placebo-controlled trial found a greater reduction in BMI z-score (0.22 SDs) in adolescents receiving liraglutide compared with placebo

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Here the authors show the efficacy of GLP1-based multi-agonists, and superiority of GLP1/E, for managing metabolic complications of PCOS in preclinical models, with improvement also of some reproductive traits.