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The time course of muscle mass loss generally parallels the rate of weight loss, with the most rapid changes occurring in the first 34 months of treatment, particularly with higher-dose agents such as semaglutide and tirzepatide

These observations are in agreement with the notion that nutrients are primarily absorbed in the proximal part of the small intestine [35]

Patients should be advised to seek immediate medical attention if they experience severe, persistent abdominal pain

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Used together, they can make this side effect far more manageable

Always consult your physician or a qualified healthcare provider for personalized medical advice and before making any decisions about your health or treatment.